Neuroglia Molecular Mechanisms in Psychiatric Disorders

Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. I...

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Main Author: Caterina Scuderi (auth)
Other Authors: Mami Noda (auth), Alexei Verkhratsky (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2019
Series:Frontiers Research Topics
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Online Access:DOAB: download the publication
DOAB: description of the publication
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520 |a Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders. 
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653 |a Neuropsychiatric Disorders 
653 |a Alcohol Use Disorders 
653 |a Neurovascular Disorders 
653 |a Neuroglia 
653 |a Schizophrenia. 
653 |a Major Depression 
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