Never-resting microglia: physiological roles in the healthy brain and pathological implications

• Main Author: Amanda Sierra (auth)
• Other Authors: Marie-Eve Tremblay (auth), Hiroaki Wake (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Neurosciences; phenotype; Neuroprotection; Disease; Health; Neurogenesis; Phagocytosis; Synapses; Microglia
• Online Access: DOAB: download the publication; DOAB: description of the publication

Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveri...