Novel Approaches to the Analysis of Family Data in Genetic Epidemiology

• Main Author: Robert C. Elston (auth)
• Other Authors: Nathan Morris (auth), Jill S. Barnholtz-Sloan (auth), Xiangqing Sun (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Genetics (non-medical); Regional heritability; prostate cancer; infectious diseases; MCMC; combining studies screening; conditional-logistic linkage; Informatics; autism
• Online Access: DOAB: download the publication; DOAB: description of the publication

Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits,...