Novel Pharmacological Inhibitors for Bacterial Protein Toxins

• Main Author: Holger Barth (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2017
• Subjects: Biology, life sciences; Bacterial AB-toxins; infection; Shiga toxin; semicarbazone EGA; pore-forming toxins; Botulinum Neurotoxin (BoNT); black lipid bilayer membrane; cellular uptake; intracellular transport; anthrax toxins; Clostridium perfringens toxins; Diphtheria toxin; Clostridium difficile toxins; pore-blockers; sialidases; translocation; binary clostridial actin ADP-ribosylating toxins; dendrimers; clostridial toxins; food-poisoning; anti-toxins; intestinal pathogenesis; pharmacological inhibitors; membrane transport; probiotic microorganisms
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication.

Physical Description

1 electronic resource (VI, 118 p.)

ISBN

9783038424307
9783038424314

Access

Open Access