Organophosphorus Chemistry 2018

• Main Author: Keglevich, György (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Chemistry; synergy; 1-(acylamino)alkylphosphonic acids; hydrolytic deacylation; chiral phosphines; organophosphorus chemistry; alcoholysis; electrophilic substitution; NORPHOS; DFT; diphosphines; dry eye syndrome; cyclo-P5; O-derivatization; triple-decker; phosphorylation; molybdenum; NMR-controlled titration; mechanochemistry; N-acyliminium cation; stability constants; Pudovik reaction; phosphonocarboxylic acids; 1; aminophosphonic acids; allylic alkylation; diquafosol; silver; Diels-Alder reaction; QTAIM; dissociation constants; weakly coordinating; substitution; phosphonium salts; amino acids; continuous flow reactor; DFT calculations; metallacycle; 31P NMR spectra of intermediates; dinucleotides; N-acylimine; copper; microwave; 1-aminoalkylphosphonic acids; phosphonic acids; bis(phosphane) palladium complex; denufosol; oxidation; C-H bond activation; asymmetric catalysis; dynamic and specific NMR parameters; electronic parameters; dialkyl H-phosphonates; ?-hydroxyphosphonate; transesterification; polycyclic compounds; stereoselective synthesis; rearrangement; hydrolysis; ?-amidoalkylating agents; 3-azaphospholes
• Online Access: DOAB: download the publication; DOAB: description of the publication

Organophosphorus chemistry is an important discipline within organic chemistry. Phosphorus compounds, such as phosphines, trialkyl phosphites, phosphine oxides (chalcogenides), phosphonates, phosphinates and >P(O)H species, etc., may be important starting materials or intermediates in syntheses. Let us mention the Wittig reaction and the related transformations, the Arbuzov- and the Pudovik reactions, the Kabachnik-Fields condensation, the Hirao reaction, the Mitsunobu reaction, etc. Other reactions, e.g., homogeneous catalytic transformations or C-C coupling reactions involve P-ligands in transition metal (Pt, Pd, etc.) complex catalysts. The synthesis of chiral organophosphorus compounds means a continuous challenge. Methods have been elaborated for the resolution of tertiary phosphine oxides and for stereoselective organophosphorus transformations. P-heterocyclic compounds, including aromatic and bridged derivatives, P-functionalized macrocycles, dendrimers and low coordinated P-fragments, are also of interest. An important segment of organophosphorus chemistry is the pool of biologically-active compounds that are searched and used as drugs, or as plant-protecting agents. The natural analogue of P-compounds may also be mentioned. Many new phosphine oxides, phosphinates, phosphonates and phosphoric esters have been described, which may find application on a broad scale. Phase transfer catalysis, ionic liquids and detergents also have connections to phosphorus chemistry. Green chemical aspects of organophosphorus chemistry (e.g., microwave-assisted syntheses, solvent-free accomplishments, optimizations, and atom-efficient syntheses) represent a dynamically developing field. Last, but not least, theoretical approaches and computational chemistry are also a strong sub-discipline within organophosphorus chemistry.