Organs-on-chips

• Main Author: Tung, Yi-Chung (auth)
• Other Authors: Torisawa, Yu-suke (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: History of engineering & technology; n/a; tissue engineering; microfluidic device; ischemia/reperfusion injury; syringe pump; liver-on-a-chip; vacuum chuck; epithelial-endothelial interface; vessel branching; organs-on-chips; nanogrooves; passive delivery; functional neuron imaging; organ-on-a-chip; lung epithelial cell; MEMS; drug absorption; strain; 3D cell culture system; mechanical cue; multi-culture; angiogenesis; high-throughput screening; fluoroelastomer; membranes; cell culture; paracellular/transcellular transport; beating force; microfabrication; drug hepatotoxicity; biomimetic oxidation; compression; microfluidics; surfactant protein; PDMS; neuronal cell networks; neuronal guidance; trans-epithelial electrical resistance; spheroid array; organ-on-a-chip (OOC); biomechanics; cell; organ-on-chips; organ-on-chip; stretch; shear stress; shear flow; image-based screening; drug metabolism; vascularization; human induced pluripotent Stem cell-derived cardiomyocytes (hiPS-CM); stress; barrier permeability; bio-mechanical property; cardiac 3D tissue; endothelial cell activation; organoid; silicon; lattice light-sheet microscopy; integrated pump; SH-SY5Y cells; thrombolysis; 3D cell culture; neuronal cells; drug efficacy; vascularized tumor model
• Online Access: DOAB: download the publication; DOAB: description of the publication

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within mi...