Perivascular Adipose Tissue (PVAT) in Health and Disease

In 1991, Soltis and Cassis (Clin Exp Hypertens A 1991 13:277-296) published the first paper that the fat tissue around an artery - perivascular adipose tissue or PVAT - changed how the artery contracted to norepinephrine. Followed later by important work showing that PVAT itself contained vasoactive...

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Bibliografische gegevens
Hoofdauteur: Maik Gollasch (auth)
Andere auteurs: Stephanie W. Watts (auth)
Formaat: Elektronisch Hoofdstuk
Taal:Engels
Gepubliceerd in: Frontiers Media SA 2018
Reeks:Frontiers Research Topics
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Samenvatting:In 1991, Soltis and Cassis (Clin Exp Hypertens A 1991 13:277-296) published the first paper that the fat tissue around an artery - perivascular adipose tissue or PVAT - changed how the artery contracted to norepinephrine. Followed later by important work showing that PVAT itself contained vasoactive molecules, the scientific community recognized that PVAT was not simply a store of fat but is a vasoactive tissue that contributes to the functioning and status of the vessel it surrounds. Our goal for this Frontiers Research Topic is to highlight the significant reach of PVAT in vascular function, from contractility to growth in health and in disease. In doing so, we explicitly place findings that can be taken advantage of in creating new therapies for cardiovascular diseases that continue to challenge our community. These include hypertension, atherosclerosis, and diabetes to name a few.
Fysieke beschrijving:1 electronic resource (158 p.)
ISBN:978-2-88945-603-1
9782889456031
Toegang:Open Access