The Physiological Functions of the Amyloid Precursor Protein Gene Family

• Main Author: Ulrike C. Muller (auth)
• Other Authors: Thomas Deller (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Amyloid precursor-like protein; learning and memory; neuroprotection; spines; synaptic plasticity; Alzheimers disease; animal model; synaptogenesis; synaptic adhesion; Amyloid precursor protein
• Online Access: DOAB: download the publication; DOAB: description of the publication

The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer's disease (AD), as proteolytical cleavage of APP gives rise to the Aß peptide which is deposited in the brains of Alzheimer patients. Despite this, our knowledge of the normal cell biological and physiological f...