The Physiological Functions of the Amyloid Precursor Protein Gene Family

• मुख्य लेखक: Ulrike C. Muller (auth)
• अन्य लेखक: Thomas Deller (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2017
• श्रृंखला: Frontiers Research Topics
• विषय: Neurosciences; Amyloid precursor-like protein; learning and memory; neuroprotection; spines; synaptic plasticity; Alzheimers disease; animal model; synaptogenesis; synaptic adhesion; Amyloid precursor protein
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer's disease (AD), as proteolytical cleavage of APP gives rise to the Aß peptide which is deposited in the brains of Alzheimer patients. Despite this, our knowledge of the normal cell biological and physiological f...