Recent Development of Electrospinning for Drug Delivery

• Main Author: Zelkó, Romána (auth)
• Other Authors: Lamprou, Dimitrios A. (auth), Sebe, István (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; antibacterial activity; piroxicam; n/a; tissue engineering; biotechnology; polydextrose; solvent casting; antibacterial; drug delivery; diabetic; pectin; nanotechnology; nanocomposite; hydroxypropyl methyl cellulose; poorly water-soluble drug; artificial red blood cells; oral dosage form; Lactobacillus; scanning electron microscopy; wound healing; UV imaging; wetting; biocompatibility; scale-up; polylactide-co-polycaprolactone; nanofibers; growth factor; drug release kinetics; hydrogel; differential scanning calorimetry; bacterial bioreporters; physical solid-state properties; PCL; coaxial spinning; drug delivery system; haemanthamine; probiotics; amphiphilic nanofibers; wound dressings; grinding; scanning white light interferometry; biopharmaceuticals; clove essential oil; viability; plant-origin alkaloid; oligochitosan; local delivery; electrospinning; Lactococcus; self-assembled liposomes; microcapsules; microfibers; nanofiber; in situ drug release; biomedical; core-sheath nanofibers; processability; polymeric carrier; aceclofenac; drying; gentamicin sulfate; traditional electrospinning; electrospinning and electrospray; fourier transform infrared spectroscopy; drug release; gelatin; ultrasound-enhanced electrospinning; 3D printing
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline-amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical-chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.

Physical Description

1 electronic resource (206 p.)

ISBN

books978-3-03928-141-1
9783039281411
9783039281404

Access

Open Access