Recent Progress in Solid Dispersion Technology

• Hoofdauteur: Kawakami, Kohsaku (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Onderwerpen: Biology, life sciences; thermodynamic modeling; molecular dynamics simulation; poorly soluble drugs; amorphous solid dispersions; dissolution enhancement; crystallization tendency; continuous processing; stability; milling; granulation; thermal analysis; amorphous; ball milling; pharmaceutical glass; dissolution; rebamipide; poloxamer; classification; polyelectrolytes; amorphisation; self-assembly; dissolution rate; miscibility; bioavailability; solubility; evaporation; mesoporous; polyelectrolyte excipient matrix; polymer; bicaludamide; phase diagram; Weibull dissolution model; spectroscopic techniques; anticancer drugs; manufacturing methods; nucleation; molecular complex; nanoaggregates; enrofloxacin; accelerated stability test; solubility enhancement; amorphous solid dispersion; tadalafil; process development; amorphous polymeric salt; Wood's apparatus; hot melt extrusion; solid dispersions; intrinsic dissolution rate; solid dispersion; interaction; crystallization; spray drying; characterization; ciprofloxacin
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Samenvatting

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Fysieke beschrijving

1 electronic resource (204 p.)

ISBN

books978-3-03921-502-7
9783039215010
9783039215027

Toegang

Open Access