The role of arginase in endothelial dysfunction

• Main Author: Rudolf Lucas (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; eNOS; Reactive Oxygen Species; L-citrulline; arginase inhibitors; vessel wall remodeling; impaired vasorelaxation; microvascular permeability
• Online Access: DOAB: download the publication; DOAB: description of the publication

In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction.