The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments

• Main Author: Manoj Kumar Jaiswal (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Mitochondria; neurodegenerative disease; Ca2+ signaling; multidrug therapy; Amyotrophic lateral sclerosis (ALS); Superoxide dismutase 1 (SOD1); Motor neuron disease (MND); excitotoxicity; Riluzole; multifactorial disease
• Online Access: DOAB: download the publication; DOAB: description of the publication

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not wel...