Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

• Main Author: Michel Kranendonk (auth)
• Other Authors: Wayne L. Backes (auth), Ulrich M. Zanger (auth), Amit V. Pandey (auth), Colin J. Henderson (auth), Yuji Ishii (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Pharmacology; POR; Pharmacogenetics; UGT; Biocatalysis; UDP-glucuronosyltransferase; Cytochrome P450; Drug metabolism; Membrane-associated progesterone receptor; PXR; Steroids
• Online Access: DOAB: download the publication; DOAB: description of the publication

Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, st...