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The Second Life of Natural Killer (NK) Cells

Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to mic...

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Bibliographic Details
Main Author: Joseph C. Sun (auth)
Other Authors: Marco Colonna (auth), Chiara Romagnani (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2018
Series:Frontiers Research Topics
Subjects:
Medicine
natural killer cells
ILC
NK cells
immune therapy
viral infection
NK cell education
immunotherapy
MHC-I
cancer
immune regulation
adaptive immunity
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Summary:Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications.
Physical Description:1 electronic resource (118 p.)
ISBN:978-2-88945-546-1
9782889455461
Access:Open Access

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