Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer

• Главный автор: Christian Diener (auth)
• Другие авторы: Osbaldo Resendis-Antonio (auth)
• Формат: Электронный ресурс Глава книги
• Язык: английский
• Опубликовано: Frontiers Media SA 2017
• Серии: Frontiers Research Topics
• Предметы: Physiology; Computational Biology; Metabolic alterations; Metabolism; Systems Biology; Modeling; Cancer
• Online-ссылка: DOAB: download the publication; DOAB: description of the publication

Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as...