Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer

• 1. autor: Christian Diener (auth)
• Kolejni autorzy: Osbaldo Resendis-Antonio (auth)
• Format: Elektroniczne Rozdział
• Język: angielski
• Wydane: Frontiers Media SA 2017
• Seria: Frontiers Research Topics
• Hasła przedmiotowe: Physiology; Computational Biology; Metabolic alterations; Metabolism; Systems Biology; Modeling; Cancer
• Dostęp online: DOAB: download the publication; DOAB: description of the publication

Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as...