Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation

• Main Author: Ciccodicola, Alfredo (auth)
• Other Authors: Casamassimi, Amelia (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; transcription factor; n/a; transcription; self-incompatibility; cytogenetics; epigenetics; selenocysteine; tea; AP-2?; nonsense-mediated decay; transcriptomics; Akt1; promoter; cell metabolism; pediveliger larvae; Patau Syndrome; tristetraprolin (TTP); long non-coding RNA (lncRNA); pregnancy; G-quadruplex; glioblastoma; placenta; PRDM gene family; circRNA-disease associations; bioadhesive; gene expression; Crassostrea gigas; transcription regulation; cell differentiation; RNA interference; transcriptome; inflammatory response; FOXO1; Adiponectin; liquid chromatograph-tandem mass spectrometer (LC-MS/MS); selenium; selenocysteine insertion sequence; inflammation; selenoproteins; research methods; nutritional status; structures and functions; CRISPR/Cas9; fertilization; melanin; differentially expressed genes; tyrosinase; posttranscriptional regulation; major depressive disorder; human malignancies; pathway; CDKN1C; transcription factors; p57Kip2; enhancer activity; mouse; disorders; high-throughput RNA sequencing (RNA-Seq); TCGA data analysis; RNA-seq; heterogeneous network; insect; and drug design; therapeutic targets; mechanisms; obesity; Pacific oyster; Rsh regulon; common pathway; Pax3; somatic mutations; nutrition; molecular docking; bioinformatics; interactome; long non-coding RNAs; transcriptional regulation; Pteria penguin (Röding; Adiponectin receptors; transcriptome profiling; 1798); N-acyl-l-homoserine lactone; ppGpp; tumorigenesis; sphingomonads; human; disease; adenosine and uridine-rich elements (AREs); progress and prospects; miR-25-3p; acute leukemia; Novosphingobium pentaromativorans US6-1; microscopy; cancer; molecular pathways; causal inference
• Online Access: DOAB: download the publication; DOAB: description of the publication

Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.