TRP Channels in Health and Disease

• Main Author: Dietrich, Alexander (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Medicine; n/a; transient receptor potential channels; photochromic ligands; elementary immunology; Purkinje cell; EPSC; substance P; chemicals; organ toxicity; lymphocytes; HSP70; physiology; bioavailable; inflammatory bowel disease; platelets; pollutants; yeast; regulatory T cells; kinase; Saccharomyces cerevisiae; manganese; cerebellum; TRP channel; NHERF; inflammation; nanoHPLC-ESI MS/MS; TRPM7; chemical probes; TRPM8; dorsal column nuclei; TRPV2; TRPV3; calcitonin gene-related peptide; TRPV1; ion channels; transient receptor potential; 2D gel electrophoresis; MALDI-TOF MS(/MS); TRPV4; overproduction; sulfur mustard; oxidative stress; graft versus host disease; menthol; topical; chemosensor; AP18; calcium signalling; mucosal epithelium; cuneate nucleus; production platform; TRPC channels; ulcerative colitis; channel structure; xerostomia; neutrophils; cardiovascular system; TRPC5; TRPC6; TRPC3; TRPC4; calcium signaling; protein purification; adipose tissue; transient receptor potential (TRP) channels; sodium; TH17; diacylglycerol; hypersensitivity; TRPY1; GABAB; HEK293; thrombosis; ion channel; TRPC; pathophysiology; SMAD; toxicology; endothelium; calcium; proteomics; TRPA1; salivary glands; TRP channels; lipid mediators; sensors; radiation; TRPM4 channel; human medulla oblongata; mGluR1; small molecules; TRPC3 pharmacology
• Online Access: DOAB: download the publication; DOAB: description of the publication

Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for "canonical", TRPA with A for "ankyrin", TRPM with M for "melastatin", TRPML with ML for "mucolipidin", TRPP with P for "polycystin", and TRPV with V for "vanilloid". Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in "Cells" summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.