Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics

• Main Author: Christian R. Gomez (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Medicine; microenvironment; Stem Cells; hypoxia; stress; HIF; tumor; Leukemia; biomarkers; therapy; pH
• Online Access: DOAB: download the publication; DOAB: description of the publication

Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adapta...