The unfolded protein response in virus infections

• Main Author: Shiu-Wan Chan (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Microbiology (non-medical); ERAD; virus-host interaction; innate immunity; Gene Therapy; Pathogenesis; Endoplasmic Reticulum Stress; Unfolded Protein Response; Autophagy
• Online Access: DOAB: download the publication; DOAB: description of the publication

Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cau...