Chapter: 'Analysis of Breast Cancer Cell Invasion Using an Organotypic Culture System' from book: 3D Cell Culture: Methods and Protocols

• Main Author: Romana E. Ranftl (auth)
• Other Authors: Fernando Calvo (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Springer Nature 2017
• Series: Methods in Molecular Biology
• Subjects: Oncology; Cancer-associated fibroblasts; Organotypic; Breast cancer; Metastasis; Invasion
• Online Access: DOAB: download the publication; DOAB: description of the publication

Metastasis is the main cause of cancer patient mortality. Local tumor invasion is a key step in metastatic dissemination whereby cancer cells dislodge from primary tumors, migrate through the peritumoral stroma and reach the circulation. This is a highly dynamic process occurring in three dimensions...