Tumor Suppressor Genes
Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which le...
Сохранить в:
| Другие авторы: | |
|---|---|
| Формат: | Электронный ресурс Глава книги |
| Язык: | английский |
| Опубликовано: |
IntechOpen
2012
|
| Предметы: | |
| Online-ссылка: | DOAB: download the publication DOAB: description of the publication |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|
| Итог: | Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies. |
|---|---|
| Объем: | 1 electronic resource (346 p.) |
| ISBN: | 1337 9789533078793 9789535167440 |
| Доступ: | Open Access |