Frontiers in Radiation Oncology
The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through H...
Saved in:
Other Authors: | |
---|---|
Format: | Electronic Book Chapter |
Language: | English |
Published: |
IntechOpen
2013
|
Subjects: | |
Online Access: | DOAB: download the publication DOAB: description of the publication |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000naaaa2200000uu 4500 | ||
---|---|---|---|
001 | doab_20_500_12854_66575 | ||
005 | 20210420 | ||
003 | oapen | ||
006 | m o d | ||
007 | cr|mn|---annan | ||
008 | 20210420s2013 xx |||||o ||| 0|eng d | ||
020 | |a 3065 | ||
020 | |a 9789535111634 | ||
020 | |a 9789535171706 | ||
040 | |a oapen |c oapen | ||
024 | 7 | |a 10.5772/3065 |c doi | |
041 | 0 | |a eng | |
042 | |a dc | ||
072 | 7 | |a MJCL |2 bicssc | |
100 | 1 | |a Kataria, Tejinder |4 edt | |
700 | 1 | |a Kataria, Tejinder |4 oth | |
245 | 1 | 0 | |a Frontiers in Radiation Oncology |
260 | |b IntechOpen |c 2013 | ||
300 | |a 1 electronic resource (228 p.) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/3.0/ |2 cc |4 https://creativecommons.org/licenses/by/3.0/ | ||
546 | |a English | ||
650 | 7 | |a Oncology |2 bicssc | |
653 | |a Radiotherapy | ||
856 | 4 | 0 | |a www.oapen.org |u https://mts.intechopen.com/storage/books/2693/authors_book/authors_book.pdf |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/66575 |7 0 |z DOAB: description of the publication |