Oligodendrocyte Physiology and Pathology Function

• Other Authors: Kipp, Markus (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; Neurosciences; plasma membrane proteins; liquid chromatography-mass spectrometry; murine acute brain slices; reproducibility; rat cerebellum; Nsun5; Williams-Beuren syndrome (WBS); corpus callosum (CC); oligodendrocyte (OL); myelination; remyelination; EGFR inhibitor; smoothened agonist; microfibers; drug screening; multiple sclerosis; cuprizone; atrophy; design-based stereology; 18F-FDG; macromolecular proton fraction; MPF; myelin; magnetic resonance imaging; cuprizone model; demyelination; oligodendrocyte precursors; oligodendrocytes; immunohistochemistry; oligodendrocyte; epigenetics; neurodegeneration; laquinimod; energy drinks; caffeine; taurine; neuron; OPC; oligodendrocyte progenitor cells; screening; nanofibers; DigiGait™; experimental autoimmune encephalomyelitis; gait analysis; schizophrenia; interneuron; pluripotent stem cells; cognition; treatment; cre-recombinase; experimental autoimmune encephalomyelitis (EAE); glial progenitor cells; tamoxifen; down syndrome; white matter; glial fate; transient receptor potential ankyrin 1; astrocyte; conditional knockout; astrocytes; white matter disease; cross-talk; CNS; glial cells.; age; microglia; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple...