Zika Virus and Host Interactions

• Other Authors: Hobman, Tom (Editor), Kumar, Anil (Editor), Limonta, Daniel (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; Zika virus; peroxisomes; innate immune response; interferon; astrocytes; fetal brain; zika virus; flaviviruses; T cells; host-pathogen interactions; flavivirus; tight junctions; claudins; ZO-1; blood-placental barrier; placenta; apoptosis; viral replication; Bcl-2 protein family; ZIKV; virus host interactions; pathogenesis; MR766; guinea pig; subcutaneous; vaginal; sexual transmission; virus transmission; envelope protein; glycosylation; fusion loop; viral fusion; cell entry; NS5 protein; nuclear localization; inflammation; innate immunity; extracellular vesicles; cellular communication; C6/36 cells; human monocytes; endothelial vascular cells; protein-protein interaction; non-structural viral proteins; network; JAK/STAT; cytokine; West Nile virus; HSP90; NS5; virus-host interactions; anti-viral signaling; immune response; inflammatory mediator; Sertoli cells; Leydig cells; ZIKA virus; arboviruses; infertility; IFN; RIG-I; MDA5; IFNAR1; zika; host; cell death; peroxisome; mosquito; tight junction
• Online Access: DOAB: download the publication; DOAB: description of the publication

Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV-host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.