From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials

• Other Authors: FESSARD, Valérie (Editor), Nesslany, Fabrice (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Humanities; Social interaction; graphene oxide; reduced graphene oxide; micronucleus; oxidative stress; safer-by-design; tungsten; nanoparticles; tritiated particles; in vitro testing; cytotoxicity; micronuclei formation; DNA damage; epigenetics; DNA methylation; BEAS-2B cells.; polystyrene nanoparticles; nanoplastics; genotoxicity; Hs27 human fibroblasts; comet assay; FPG enzyme; TiO2NP; SiO2NP; ZnONP; CeO2NP; AgNP; multi-walled carbon nanotubes (MWCNT); titanium dioxide nanoparticles; lincomycin; human amniotic cells; in vitro genotoxicity; apoptosis; nanotoxicology; metal oxides; high throughput screening; micronucleus assay; nanomaterial; aluminum; oral route; gut; liver; V79 cells; Hprt; advanced in vitro model; hepatotoxicity; liver spheroids; 3D culture; HepG2; nongenotoxic silver nanoparticles; genotoxic; cytotoxic; antioxidant activity; silver ions; Allium cepa; metal/coating agent ratio; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage-the first step in carcinogenesis-must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.

Physical Description

1 electronic resource (188 p.)

ISBN

books978-3-0365-0113-0
9783036501123
9783036501130

Access

Open Access