Drug Delivery of siRNA Therapeutics

• Other Authors: Lamberti, Gaetano (Editor), Angela Barba, Anna (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; oligonucleotide delivery; light-activated release; intracellular release; liposome; indocyanine green; drug co-delivery; methotrexate; siRNA; antitumor effect; mixed micelles; targeted delivery system; cationic liposome; folate; folate receptor; cationic cholesterol derivative; siRNA delivery; gene knockdown; tumor-targeting; VEGFA; VEGFR1; endoglin; peptide; angiogenesis; gene silencing; migration; proliferation; endothelial cells; RNAi therapeutics; amphiphilic dendrons; PAMAM dendrimers; self-assembling; nanovectors; covalent dendrimers; NABDs; liposomes; clinical trials; drug delivery; nanoparticle; carbonate apatite; ERBB2; AKT; breast cancer; ovarian cancer; polymer; lipid; delivery; poly(ethylene) imine; PEI; RNA; tyrosine-modification; tumor xenograft; magnetic nanoparticle; iron oxide; BCL2; BIRC5/survivin; oral cancer; aptamers; cancer; nanoparticles; STAT6; polyaspartamide; pegylation; polyamine; polyplexes; asthma; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for g...