Bioinorganic Chemistry of Nickel

• Other Authors: Maroney, Michael J. (Editor), Ciurli, Stefano (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; InrS; nickel-dependent transcriptional regulators; molecular modelling; nickel; hydrogenase; urease; Ni-enzymes; pathogens; ncRNA; miRNA; lncRNA; lung carcinogenesis; histidine-rich protein; carbon monoxide dehydrogenase; nickel chaperone; nickel-induced oligomerization; urease maturation; metallochaperone; G-protein; conformational change; bioavailability; carcinogenicity; genotoxicity; allergy; reproductive; asthma; nanoparticles; ecotoxicity; environment; biological nickel sites; nickel-thiolates; dinuclear nickel metallopeptides; thiolate oxidative damage; nickel enzymes; reaction mechanism; quantum chemical calculations; glyoxalase; streptomyces; mycothiol; metalloenzyme; AD11; nickel-dependent enzyme; methionine salvage pathway; methionine; S-adenosylmethionine (SAM); methylthioadenosine (MTA); enolase phosphatase 1 (ENOPH1); polyamine; matrix metalloproteinase MT1 (MT1-MMP); metalloregulator; chaperone; [NiFe]-hydrogenase; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using str...