Natural Products and Neuroprotection

• Other Authors: Angeloni, Cristina (Editor), Vauzour, David (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; Vitamin D; Multiple Sclerosis; symptom; neurodegeneration; oxidative injury; Parkinson's disease; terpenes, rotenone; thymol; Alzheimer's disease; Centella asiatica; hippocampus; protein poshophatase 2; glycogen synthase kinase 3; B-cell lymphoma 2; neuroprotection; nutraceuticals; bioavailability; stress response; neurodegenerative disease; bioactive compound; natural extract; β-amyloid peptide; tau protein; clinical trial; human studies; animal studies; in vitro studies; curcumin; free radicals; heme oxygenase; safety profile; type 2 diabetes; inflammation; vascular damage; learning; memory; natural compound; oxidative stress; cognitive dysfunction; cell death; synapse loss; protein aggregation; neuroinflammation; algae; seaweeds; neurodegenerative diseases; auraptene; dopamine neuron; antioxidant; mitochondria; Chionanthus retusus; flavonoid; flower; HO-1; NO; Lippia citriodora; VEE; Vs; relaxation; depression; cyclic AMP; calcium; blood-brain barrier; catechin; cognition; epigallocatechin gallate; green tea; microbiota; 5-(3,5-dihydroxyphenyl)-γ-valerolactone; ascaroside pheromone; C. elegans; dauer; neuronal signaling; sexual behavior; survival signals; proteostasis; chaperones; autophagy; ubiquitin-proteasome; unfolded protein response; natural compounds; natural products; ethics; patients' autonomy; beneficence; nonmaleficence; medical liability; Parkinson's disease (PD); mitochondrial dysfunction; dynamics; hormesis; ubiquitin‒proteasome system (UPS); mitophagy; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.