Mitogen Activated Protein Kinases Functions in Signal Transduction and Human Diseases

• Other Authors: Tikkanen, Ritva (Editor), Nikolic-Paterson, David (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; Rabdosia inflexa; inflammation; gastric ulcer; cytokines; MAPK; NF-κB; extracellular signal-regulated kinases 1/2; hyperoxia; bronchopulmonary dysplasia; HPAECs; angiogenesis; cell cycle; SIRT1; oxidative stress; psoriasis; antimicrobial peptide; cecropin A; tight junction protein; MEK/ERK signaling; porcine intestinal epithelial cell; extracellular signal-regulated kinase 5 (ERK5); Kv4.2; PC12 cells; infantile myofibromatosis; receptor tyrosine kinases; platelet-derived growth factor receptor; protein kinase inhibitors; sunitinib; erlotinib; FR180204; U0126; targeted therapy; apoptosis; ERK1/2; JNKs; mitochondrial dysfunction; neurodegeneration; neuro-inflammation; p38 MAPKs; Parkinson's disease; mitogen-activated protein kinases (MAPKs); MAPK kinetics; osteoclast differentiation; bone remodeling; DAPK; ERK; p38; JNK; mitogen-activated protein kinase pathway (MAPK pathway); protein tyrosine phosphatase interacting protein 51 (PTPIP51); protein-protein interaction (PPI); cancer signaling; SR; CR; Compatibility; T2DM; metabolic profiling; MAPK/PI3K/Akt signaling pathway; reactive oxygen species; PTPN6; SRC; DOK4; MKK4; MKK7; p53; DUSP1; SIRT2; atherosclerosis; aortic valve sclerosis; aortic valve stenosis; naphthalimide-metal complex conjugates; N-heterocyclic carbene; mitochondria; ROS; p38 MAPK; cancer; FGF-induced signaling; FRS2; phosphorylation; downregulation; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.