Epithelial-Mesenchymal Plasticity in Cancer Metastasis Molecular Reprogramming, Cellular Adaptation, and Clinical Implications

• その他の著者: Jolly, Mohit Kumar (編集者), Celia-Terrassa, Toni (編集者)
• フォーマット: 電子媒体 図書の章
• 言語: 英語
• 出版事項: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• 主題: Medicine
• オンライン･アクセス: DOAB: download the publication; DOAB: description of the publication

要約

Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.

物理的記述

1 electronic resource (512 p.)

ISBN

books978-3-03936-725-2
9783039367245
9783039367252

アクセス

Open Access