Microbial Virulence Factors

• Other Authors: Leitão, Jorge H. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; Aeromonas hydrophila; LysR-family; ΔlahS; global regulator; virulence; Sclerotinia sclerotiorum; SsNsd1; compound appressorium; two-dimensional electrophoresis; proteomics analysis; differential expression proteins; cystic fibrosis; Pseudomonas aeruginosa; Burkholderia cepacia complex; small noncoding regulatory RNAs; pathogenicity; usg; truA; Salmonella enterica serovar Typhimurium; oxidative stress; intracellular survival; pathogenomics; coagulase-negative staphylococci; virulence factors; whole genome sequencing; autotransporter; covalent labeling; bacterial surface protein; SpyCatcher; topology mapping; virulence factor; Candida; host-pathogen interaction; biofilm formation; morphology; immune evasion; Trueperella pyogenes; pyolysin; infection; immune response; Actinomycetales; Bordetella pertussis; Hfq; omics analysis; T3SS; serum resistance; solute-binding proteins; phytoplasma; effector protein; apple; apple proliferation; bacteria; blood-brain barrier; blood-cerebrospinal fluid barrier; meningitis; outer membrane vesicles (OMVs); Candida albicans; antimicrobial peptides; complement; interspecies interactions; inter-kingdom protection; fungicidal activity; fluconazole; hyphae; antimicrobial peptide; EDTA; primary ciliary dyskinesia; anti-virulence; sputum; chronic infection; Enterobacterales; Klebsiella; Enterobacter; Citrobacter; antibiotic resistance; biofilm; SPATEs; UTIs; cytotoxicity; serine proteases; 5637 bladder cells; mucin; gelatin; actin; protease Lon; Dickeya solani; plant pathogen; motility; type III secretion system; resistance to stress; lon expression; pectinolytic enzymes; gene expression; manipulation; inflammation; persistence; replicative niche; actin proteolysis; metalloproteinases; protease ECP 32; grimelysin; protealysin; bacterial invasion; microbial virulence factors; bacterial pathogens; fungal pathogens
• Online Access: DOAB: download the publication; DOAB: description of the publication

Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.