Rheumatoid Arthritis Therapy Reappraisal Strategies, Opportunities and Challenges

• Other Authors: Müller, Rüdiger (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; rheumatoid arthritis; sleep; sleep disorders; pain; osteoporosis; fracture; fracture risk assessment tool; treat-to-target; certolizumab pegol; csDMARDs; glucocorticoids; intra-articular injections; DAS 28; ACR response; HAQ-DI; TNFα; golimumab; efficacy; tolerability; immunogenicity; methotrexate; posology; titration; oral route; subcutaneous route; bioavailability; effectiveness; periodontitis; periodontal disease; anti-citrullinated protein autoantibodies; rheumatoid factor; smoking; medication; Porphyromonas gingivalis; Rheumatoid arthritis; matrix metalloproteinase 3; infliximab; pharmacogenomics; anti-TNF; personalized medicine; baricitinib; disease-modifying antirheumatic drugs; pain perception; outcomes research; patient perspective; Rheumatoid Arthritis; therapy; DMARD; MTX; Tumor Necrosis Factor-Alpha Inhibitors; ankylosing spondylitis; biosimilar; switching; synovial fibroblasts; cytokine; osteoclast; herbal medicine; methylation; next-generation sequencing; recovery of function; fatigue; productivity; tofacitinib; oral; Th1.17; IL-17A; IFN-γ, CD73; adenosine; psoriatic arthritis; regulation; pseudoerosions; hand; foot; ultrasonography; radiography; computed tomography; magnetic resonance imaging; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Rheumatoid Arthritis (RA) is a chronic inflammatory disease leading to joint inflammation and destruction. Treatment of RA includes the use of conventional (cs), biologic (b) disease-modifying anti-rheumatic drugs (DMARDs), and oral or intraarticular (IA) glucocorticoids (GCs). All different classes of drugs have shown to halt disease progression in clinical studies. In real life, a physician has more options than just adding or switching to a new ts/bDMARD if any kind of DMARDs has failed. They can modify or optimize the therapy with concomitant csDMARDs, and oral or IA-GC can be added to the treatment regimen. The EULAR states that therapeutic adjustment including the "optimization of csDMARDs dose or route of administration or intra-articular injections of GCs" is recommended. Thus, a new therapeutic agent can be embedded in a whole strategy with parallel optimization of the csDMARD and GC treatment. The idea of treating to target (T2T) for the treatment of RA patients has been around since the late 1990s. Many clinical studies (Ticora, BsSt, Camera) have demonstrated the superiority of a T2T approach. When I talk to physicians, I understand that most of them only rarely inject joints with GC. Therefore, I would like to create an issue on the T2T approach in reality including primary data, reviews, and real-life data demonstrating the general opinion and execution of T2T in treating RA.

Physical Description

1 electronic resource (260 p.)

ISBN

books978-3-03943-091-8
9783039430901
9783039430918

Access

Open Access