Antitumoral Properties of Natural Products Volume 2

Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive mole...

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Bibliographic Details
Other Authors: Fabiani, Roberto (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:
JNK
AR
ASE
TP
Akt
AKT
ROS
LC3
p38
n/a
Online Access:DOAB: download the publication
DOAB: description of the publication
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520 |a Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment. 
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653 |a cytotoxic activity 
653 |a NCI-60 cancer cell line 
653 |a pristimerin 
653 |a Salacia crassifolia 
653 |a Celastraceae 
653 |a Brazilian Cerrado biome 
653 |a Salacia elliptica 
653 |a Cheiloclinium cognatum 
653 |a Plenckia populnea 
653 |a Aspergillus fumigatus 
653 |a Cordyceps sinensis 
653 |a isochromanes 
653 |a chiral resolution 
653 |a ECD calculation 
653 |a cytotoxicity 
653 |a coronarin D 
653 |a JNK 
653 |a osteosarcoma 
653 |a Zeylenone 
653 |a gastric cancer 
653 |a invasion 
653 |a migration 
653 |a apoptosis 
653 |a anti-cancer agents 
653 |a anthraquinones 
653 |a glycosyltransferase 
653 |a Dendrobium officinale 
653 |a structure elucidation 
653 |a anti-tumor activity 
653 |a plantation mode 
653 |a AR 
653 |a Ganoderma tsugae 
653 |a lipogenesis 
653 |a prostate cancer 
653 |a SREBP-1 
653 |a ursolic acid 
653 |a betulinic acid 
653 |a triterpenoids 
653 |a necrotic 
653 |a quercetin 
653 |a quercetagetin 
653 |a patuletin 
653 |a lichen 
653 |a secondary metabolites 
653 |a tumidulin 
653 |a stemness potential 
653 |a colorectal cancer cells 
653 |a oncogene 
653 |a transcriptional regulation 
653 |a neferine 
653 |a FAK/S6K1 
653 |a autophagy 
653 |a human neuroblastoma cells 
653 |a natural yellow Monascus pigments 
653 |a water-soluble 
653 |a antioxidation 
653 |a MCF-7 cells 
653 |a phloretin 
653 |a cell proliferation 
653 |a inflammation 
653 |a glucose uptake 
653 |a Catalpa speciosa 
653 |a Taxus cuspidata 
653 |a Magnolia acuminata 
653 |a phenols 
653 |a antioxidants 
653 |a anticancer 
653 |a Colocasia esculenta 
653 |a food bioactive 
653 |a tarin 
653 |a stable nanocapsules 
653 |a entrapment efficiency 
653 |a no-toxicity 
653 |a preclinical tests 
653 |a antitumoral activity 
653 |a chemotherapeutic adjuvant 
653 |a grape leaves 
653 |a ASE 
653 |a TP 
653 |a Antioxidant activities 
653 |a Antiproliferative 
653 |a pro-apoptotic effects 
653 |a Gene expression 
653 |a Nutraceuticals 
653 |a Cucurbitacin B 
653 |a gefitinib-resistant NSCLC 
653 |a EGFR 
653 |a lysosomal degradation 
653 |a CIP2A 
653 |a zerumbone 
653 |a cancer 
653 |a NF-κB 
653 |a IL-6/JAK2/STAT3 
653 |a Akt 
653 |a FOXO1 
653 |a multiple myeloma 
653 |a quality control 
653 |a naringenin 
653 |a flavonoids 
653 |a traditional preparation 
653 |a cancer stem cells 
653 |a phytochemicals 
653 |a plant-derived foods 
653 |a fruit 
653 |a vegetable 
653 |a cell signaling 
653 |a Artemisia absinthium 
653 |a endoplasmic reticulum stress 
653 |a mitochondrial-dependent pathway 
653 |a melanoma 
653 |a bee venom 
653 |a melittin 
653 |a temozolomide 
653 |a AKT 
653 |a MAPK 
653 |a antrodin C 
653 |a mTOR 
653 |a metabolic stability 
653 |a capsazepine 
653 |a inflammatory diseases 
653 |a ROS 
653 |a TRPV1 
653 |a PI3K/AKT/mTOR 
653 |a CLE-10 
653 |a LC3 
653 |a MDA-MB-231 
653 |a lactoferrin hydrolysate 
653 |a copper 
653 |a manganese 
653 |a gastric cancer cells 
653 |a anti-cancer activity 
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653 |a glioblastoma 
653 |a mesenchymal stem cells 
653 |a microenvironment 
653 |a plant lectin 
653 |a protease inhibitor 
653 |a cryptolepine 
653 |a neocryptolepine 
653 |a isocryptolepine 
653 |a antiproliferative activity 
653 |a structure activity relationships 
653 |a Licochalcone A 
653 |a ATM-Chk2 
653 |a 13-ethylberberine 
653 |a mitochondrial ROS 
653 |a RT-R breast cancer cells 
653 |a diallyl disulfide 
653 |a PI3K/Akt/mTOR pathway 
653 |a Pulsatilla saponin D 
653 |a SB365 
653 |a glioblastoma multiforme 
653 |a autophagic flux inhibition 
653 |a lysosomal membrane permeabilization 
653 |a mitochondrial membrane potential 
653 |a CLEFMA 
653 |a p38 
653 |a proanthocyanins 
653 |a TNF-α 
653 |a lung adenocarcinoma 
653 |a natural compounds 
653 |a cervical cancer 
653 |a cell cycle arrest 
653 |a dicentrine 
653 |a metastasis 
653 |a glioma 
653 |a semi-synthetic derivative 
653 |a ingenol 
653 |a Euphorbia tirucalli 
653 |a protein kinase C 
653 |a seaweed 
653 |a porphyran 
653 |a carrageenan 
653 |a anti-cancer 
653 |a natural products 
653 |a n/a 
856 4 0 |a www.oapen.org  |u https://mdpi.com/books/pdfview/book/2882  |7 0  |z DOAB: download the publication 
856 4 0 |a www.oapen.org  |u https://directory.doabooks.org/handle/20.500.12854/69110  |7 0  |z DOAB: description of the publication