Hedgehog Signaling in Organogenesis and Tumor Microenvironment

• अन्य लेखक: Shimo, Tsuyoshi (संपादक)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• विषय: Medicine; Cyp26 enzymes; congenital anomalies; CRE/LoxP; hedgehog signaling; mouse models; retinoic acid; smoothened; sonic hedgehog; sonic hedgehog (SHH); oral squamous cell carcinoma (OSCC); tumor microenvironment (TME); tumor-associated macrophages (TAMs); cancer-associated fibroblasts (CAFs); tumor-associated angiogenesis; hedgehog; growth plate; endochondral ossification; chondrocyte; osteoblast; bone disease; TMJ; synovial joint; articular disc; Ihh; PTHrP; osteoarthritis; epithelial-mesenchymal interaction (EMI); prostate cancer; external genitalia; androgen; basement membrane; bone morphogenetic protein; stem cell; animal experiment; fracture healing; cancer stem cells; hypospadias; urethra; penis; bone; hedgehog signalling; tooth development; epithelial and mesenchymal interaction; Gli1; mesenchymal stem cell; lineage tracing analysis; stem cell marker; n/a
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with...