Killing Cancer Discovery and Selection of New Target Molecules

• Other Authors: Kallunki, Tuula (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; ferlin; myoferlin; dysferlin; otoferlin; C2 domain; plasma membrane; sulconazole; NF-κB; IL-8; mammosphere; breast cancer stem cells; AF1Q; MLLT11; WNT; STAT; esophageal cancer; prognosis; mTORC1; mTORC2; metabolism; rapalogs; mTOR inhibitors; cancer metabolism; mTOR in immunotherapy; nutrient metabolism; kinase inhibitors; mTOR signaling; MAPK kinase; ERK1; ERK2; CD domain; Rolled; SCH772984; VRT-11E; sevenmaker; cancer therapy; EMT; lysosome; lysosome-mediated invasion; MZF1; phosphorylation; PAK4; SUMOylation; transcription factor; zinc finger; glucocorticoids; 3D growth; nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB); epithelial-mesenchymal transition; anoikis; proliferation; targeted cancer therapy; disulfiram; NPL4; replication stress; DNA damage; BRCA1; BRCA2; ATR pathway; PDAC; TCIRG1; ATP6V0a3; invasion; migration; matrix degradation; pH-regulation; autophagy; multidrug resistance in cancer; drug efflux pumps; ATP-binding cassette transporter; breast cancer resistance protein (BCRP); ABCG2; pyrazolo-pyrimidine derivative; SCO-201; colorectal cancer; immunotherapy; inflammation; microsatellite instability; oncofetal chondroitin sulfate; chondroitin sulfate; cancer; solid tumors; target; pediatric cancer; VAR2; dexamethasone; thyroid cancer; microgravity; space environment; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more...