Genomics and Models of Nerve Sheath Tumors

• Other Authors: Hirbe, Angela C. (Editor), Pratilas, Christine A. (Editor), Dodd, Rebecca D. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; neurofibromatosis type 1; nerve sheath tumor; cancer; latent variables; machine learning; supervised learning; transfer learning; random forest; metaVIPER; tumor deconvolution; neurofibromatosis; malignant peripheral nerve sheath tumor; MPNST; polycomb repressive complex; PRC2; NF1; kinase; kinome adaptation; kinome reprogramming; MET; MEK; doxorubicin; capmatinib; tram; genomics; tumor evolution; pathology; next generation sequencing; clinical genetics; malignant peripheral nerve sheath tumors; plexiform neurofibromas; Schwann cells; neurofibromatosis type 1 syndrome; neurofibromin 1; genetically engineered mouse models; heterogeneity; CRISPR/Cas9; mouse models; sarcoma; tumor microenvironment; neurofibromatosis 1 (NF1); mebendazole (MBZ); COX-2 inhibitor; malignancy; chemoprevention; nerve sheath tumors
• Online Access: DOAB: download the publication; DOAB: description of the publication

Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST)....