The Tight Junction and Its Proteins: More Than Just a Barrier More Than Just a Barrier

• Other Authors: Fromm, Michael (Editor), Krug, Susanne M. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; tissue barrier; tight junction; claudins; tricellulin; tight junctions; organ preservation; intestine; transplantation; ischemia; intestinal mucosa; lung; epithelia; interleukin 13; UBE2Z; ubiquitin; osmolality; hydrostatic pressure; cancer; sensor; tricellular tight junctions; endometrial cancer; epithelial barrier dysfunction; Claudin-7; permeability; WNK4; epithelial sodium channel (ENaC), collecting duct cells; claudin-1; hydrogen peroxide; phosphorylation; claudin; angulin; drug development; angubindin-1; Clostridium perfringens enterotoxin; Clostridium perfringens iota-toxin; antibody; Mz-ChA-1 cells; biliary epithelial cells; phosphatidylcholine; mucus; paracellular transport; atopic dermatitis; cytokines; STAT3; ZO-2; cholestasis; gene transcription; hypertrophy; tumor suppressor; NLS; NES; CaSR; RhoA; barrier function; paracellular permeability; antidiuretic hormone; Claudin-14; CLDN14; hearing loss; vestibular function; cochlear implantation; Hepatitis C Virus; viral entry; epidermal barrier; reconstructed human epidermis; claudin targeting; Campylobacter jejuni; curcumin; apoptosis; co-culture; mouse colon; TNF; NFκB; lipolysis-stimulated lipoprotein receptor (LSR); epithelial barrier; cell-cell contact; caspase; kidney stones; ion reabsorption; quercetin; brain barriers; blood-brain barrier; neurovascular unit; blood-cerebrospinal fluid barrier; arachnoid barrier; glia limitans; adherens junctions; paracellular sodium transport; thick ascending limb; nephropathy; HELIX syndrome; hypokalemia; hypermagnesemia; anhidrosis; gland dysfunction; aging; mutations; kidney; liver; skin; human; mice; disease; in silico; drug discovery; membrane proteins; protein interactions; molecular dynamics; antibiotic-associated hemorrhagic colitis; Klebsiella oxytoca; tight junction assembly; monocytes; celiac disease; claudin-2; epithelium; inflammation; fibrosis; proliferation; migration; tricellular tight junction; paracellular water transport; tight epithelium; MDCK C7 cells; cell growth; endothelia; adherens junction; apical junctional complex; AMP-activated protein kinase (AMPK); paracellular barrier; protein structure; protein domain; occludin; junctional adhesion molecule; zonula occludens; MAGUK proteins; PDZ domain; stem cell; chemoresistance; retinal pigment epithelium; retinopathy; barrier formation; collecting duct; claudin-5; neuropathic pain; nerve injury; dorsal root ganglion; enteropathogenic E. coli (EPEC); tight junctions (TJ); polarity; atypical aPKCζ; transepithelial electrical resistance (TER); sorting nexin 9 (SNX9); EspF; claudin 1; tumor; metastasis; epithelial to mesenchymal transition; cerebral cavernous malformation; endothelial barrier; Rho; ROCK; MEKK3; ion transport; ion channel; super-resolution microscopy; structured illumination microscopy; stimulated emission depletion; single molecule localization microscopy; Claudin; blood-biliary barrier; chronic liver disease; hepatocellular carcinoma; cholangiocellular carcinoma; NISCH syndrome; repair; NHE2; ClC-2; inflammatory bowel disease; mucosal immunology; ZO-1; actomyosin; aquaporin; drinking rate; epithelial fluid transport; enterocyte; osmoregulation; paracellular; proximal tubule; calcium permeability; claudin-12; paracellular channels and barriers; cell polarity; pathogens; immune cells; environmental sensors
• Online Access: DOAB: download the publication; DOAB: description of the publication

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly the two families of claudins and TAMPs-several other functions have been discover...