New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies

• Other Authors: Cavallaro, Ugo (Editor), Giordano, Marco (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; Cadherin 11; WNT signaling; β-catenin; cancer stem cells; TNBC; early breast cancer; bevacizumab; neoadjuvant chemotherapy; ALDH1; solid cancer; chemo-resistance; HDAC inhibitors; head and neck squamous cell carcinoma; SRC; dasatinib; saracatinib; EC-8042; Ovarian cancer; Wnt signaling; tumor progression; therapy resistance; exosomes; oral cancer risk; oral epithelial dysplasia; SOX2; immunohistochemistry; oral squamous cell carcinoma; genome-wide; transcriptome; lung cancer; ATAC-seq; RNA-seq; CSCs; NSCLC; B4GALT1; LUAD; breast cancer; lipid; metabolism; therapeutic resistance; bowel cancer; organoid; tumoroid; colorectal; colon; stem cell; chemotherapy resistance; ovarian cancer; cancer stem cell; genetic heterogeneity; SNP array; L1CAM; chemoresistance; epithelial-mesenchymal transition; cancer therapy; cell adhesion molecule
• Online Access: DOAB: download the publication; DOAB: description of the publication

The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological charact...