Immunohistochemical Expression

• Other Authors: Caltabiano, Rosario (Editor), Loreto, Carla (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; training exercise; NGAL; VDR; kidney; heart; immunohistochemistry; ABCB5; uveal melanoma; prognosis; metastasis; pericardium; cytokeratin; c-kit; PDGFR; initial lymphatics; macroH2A; prognostic factor; SLC22A12; URAT1; hypouricemia; uric acid transporters; excretion fraction of uric acid; Hsp27; Hsp60; Hsp70; Hsp90; molecular chaperone; chaperonopathies; thyroid; follicular adenoma; follicular carcinoma; differential diagnosis; carcinogenesis; matrix metalloproteinases; temporomandibular joint disorder; temporomandibular joint; DEN; liver; inflammation; ultra-structural changes; oxidative stress; EGCG; Vitamin D; prostate cancer; urinary tract malformations; megacystis; enteric nervous system; outcome and prognosis; WT1; human embryonal/fetal tissues; neoplastic tissue; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists' practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody-antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice.