Toxin-Antitoxin Systems in Pathogenic Bacteria

• Other Authors: Alonso, Juan Carlos (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; tuberculosis; toxin-antitoxin systems; bacterial cell death; NAD+; stress-response; toxin-antitoxin system; mazF; type II; toxin; mRNA interferase; X-ray crystallography; cognate interactions; cross-interactions; molecular insulation; antitoxin; TA systems; addiction; anti-addiction; type I toxin-antitoxin system; small protein toxin structure; Fst/Ldr family; toxin-antitoxin; M. tuberculosis; bacteria; pathogenesis; protein-protein interactions; cross-talk; protein interface; tolerance; persistence; cross-resistance; PemI/PemK; Klebsiella pneumoniae; toxin activation; antibacterial agents; bacterial persistence; Stenotrophomonas maltophilia; opportunistic pathogen; clinical origin; environmental origin; biofilm; antibiotic resistance; cell wall inhibition; nucleotide hydrolysis; uridine diphosphate-N-acetylglucosamine; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Bacterial toxin-antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential...