Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0

• Other Authors: Dansette, Patrick M. (Editor), Werck, Danièle (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Antibiotics; Bacillus; biosynthetic gene clusters; comparative analysis; cytochrome P450 monooxygenase; Mycobacterium; P450 diversity percentage; P450 profiling; secondary metabolites; NADPH-cytochrome P450 reductase (CPR); microsomal cytochrome P450 (CYP); Cytochrome b5 (CYB5); protein dynamics; electron-transfer (ET); protein-protein interaction; cytochromes P450; CYP3A4; active site access channels; cavities boundaries; minimal cost paths; CYP139A1; genome data mining; host metabolism; Mycobacterium tuberculosis; polyketides; tuberculosis; cryptococcus; cryptococcus neoformans; CYP51; fungal pathogens; genome data-mining; human pathogens; CYP diversity analysis; tremellomycetes; trichosporon; mechanism-based inhibitor; crystal structure; CYP4 genes; genetic polymorphisms; 20-HETE; fatty acid; arachidonic acid; SNPs; molecular functionality; metabolism; lamellar ichthyosis; Bietti's crystalline dystrophy; cytochrome P450; isoform; membrane protein; protein-membrane interactions; enzyme substrate specificity; mutagenesis; molecular dynamics simulation; Sogatella furcifera; sulfoxaflor; transcriptome; RNA interference; CYP2C8; polymorphisms; reactive oxygen species; paclitaxel; cytochrome P450 reductase; electron transfer; extracellular vesicles; exosomes; extrahepatic tissues; plasma; circulatory CYPs; CYP450; drug metabolism; precision Cardio-Oncology; precision medicine; systems medicine; cytochromes P450 monooxygenases; Cyanobacteria; gene-cluster diversity percentage; mathematical formula; phylogenetic analysis; Streptomyces; cytochrome P450 monooxygenases; terpenes; P450 blooming; non-ribosomal peptides; cytochrome P450 monooxygenenases; CYP128A1; Mycobacterium tuberculosis H37Rv; molecular dynamic simulations; azole drugs; menaquinone
• Online Access: DOAB: download the publication; DOAB: description of the publication

This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in ins...