Intrinsically Disordered Proteins and Chronic Diseases

• Other Authors: Kulkarni, Prakash (Editor), Uversky, Vladimir N. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; IDP; fuzzy interactions; protein complementation assays; split-GFP reassembly; kinetics; membraneless organelles; optical tweezer; liquid-liquid phase separation; protein diffusion; depletion interaction; entropic force; low-complexity sequences; intrinsically disordered proteins; PAGE4; conformational plasticity; order-disorder transition; phosphorylation; intrinsic disordered protein; extremely fuzzy complex; protein interaction; binding mechanism; tumor protein p53; mouse double minute 2; mouse double minute 4; Kinase-inducible domain interacting domain; phosphomimetics; nuclear magnetic resonance; transient secondary structure; COR15A; Late embryogenesis abundant; Trifluoroethanol; Nuclear magnetic resonance; intrinsically disordered regions; functional segments; disease-related proteins; protein-protein interaction; subcellular location; glucocorticoid receptor; intrinsically disordered; transactivation activity; gene regulation; coactivators; microtubule associated protein; tau; intrinsically disordered protein; dynamic configuration; free energy landscape; microtubules; electrostatics; diffusion; protein structure prediction; molecular modelling; molecular dynamics; tau-microtubule association; conformational ensemble; replica exchange molecular dynamics; drug design; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidatin...