Sphingolipids From Pathology to Therapeutic Perspectives - A Themed Honorary Issue to Prof. Lina Obeid

• Other Authors: van Echten-Deckert, Gerhild (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; S1P receptor; inflammation; S1P transporter; spinster homolog 2; barrier dysfunction; anxiety; depression; sphingolipids; sphingomyelinase; ceramidase; Smpd1; acid sphingomyelinase; forebrain; depressive-like behavior; anxiety-like behavior; ceramide; ceramides; ceramidases; neurodegenerative diseases; infectious diseases; sphingosine 1-phoshate; sphingosine 1-phosphate receptor; S1P1-5; sphingosine 1-phosphate metabolism; sphingosine 1-phosphate antagonistst/inhibitors; sphingosine 1-phosphate signaling; stroke; multiple sclerosis; neurodegeneration; fingolimod; Sphingosine-1-phosphate; obesity; type 2 diabetes; insulin resistance; pancreatic β cell fate; hypothalamus; sphingosine-1-phosphate; ischemia/reperfusion; cardioprotection; vasoconstriction; coronary flow; myocardial function; myocardial infarct; albumin; type 1 diabetes; beta-cells; islets; insulin; cytokines; S1P; animal models; cystic fibrosis; autophagy; myriocin; Aspergillus fumigatus; CLN3 disease; Cln3Δex7/8 mice; flupirtine; allyl carbamate derivative; apoptosis; cancer; gangliosides; immunotherapy; metastasis; phenotype switching; sphingosine 1-phosphate; Sphingosine 1-phosphate (S1P); S1P-lyase (SGPL1); tau; calcium; histone acetylation; hippocampus; cortex; astrocytes; neurons; sphingosine kinase; G-protein-coupled receptors; Gαq/11; n/a; sphingosine kinase 1; SK1; microRNA; transcription factor; hypoxia; long non-coding RNA
• Online Access: DOAB: download the publication; DOAB: description of the publication

Although sphingolipids are ubiquitous components of cellular membranes, their abundance in cells is generally lower than glycerolipids or cholesterol, representing less than 20% of total lipid mass. Following their discovery in the brain-which contains the largest amounts of sphingolipids in the bod...