Protein-Ligand Interactions: Target Identification and Drug Discovery

• অন্যান্য লেখক: Altieri, Fabio (সম্পাদক)
• বিন্যাস: বৈদ্যুতিক গ্রন্থের অধ্যায়
• ভাষা: ইংরেজি
• প্রকাশিত: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• বিষয়গুলি: Research & information: general; Chemistry; serum half-life extension; fatty acid conjugation; FcRn-mediated recycling; serum albumin; translocator protein (TSPO); CoCl2; mitochondrial membrane potential; reactive oxygen species (ROS); cell viability; cell death; lung cancer cell line; acetylcholinesterase; amyloid beta aggregation; neuroprotection; molecular docking; multi-target drug; structure-activity relationship; brassicasterol; phytosterols; HSV; Mycobacterium tuberculosis; HSV-1 DNA polymerase; HSV-1 TK; human CDK2; ACE; UDP-galactopyranose mutase; heat shock protein 70; Hsp70; piperine; fluorescence spectroscopy; molecular dynamics; molecular biophysics; GADD45β; MKK7; multiple myeloma; protein-ligand interaction; STD-NMR; sigma receptors; sigma ligands; cancer; SIGMAR1; PGRMC1; TMEM97; NCI60 COMPARE analysis; membrane; lipid-protein interaction; lipid signalling; kinase regulation; phosphatidylinositols; molecular docking simulation; target identification; small-molecule derivatives of salicylanilide; drug discovery; drug development; thyroid diseases; endocrine disruptor compound; human umbilical artery; vascular homeostasis
• অনলাইন ব্যবহার করুন: DOAB: download the publication; DOAB: description of the publication

সংক্ষিপ্ত

Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials.

দৈহিক বর্ননা

1 electronic resource (184 p.)

আইসবিএন

books978-3-0365-1051-4
9783036510507
9783036510514

প্রবেশাধিকার

Open Access