Spumaretroviruses

• Weitere Verfasser: Khan, Arifa (Herausgegeben von), Löchelt, Martin (Herausgegeben von), Lindemann, Dirk (Herausgegeben von)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Schlagworte: Medicine; Neurosciences; spumavirus; feline illness; proviral load; neglected virus; bovine foamy virus; infectious clone; particle release; cell-free transmission; foamy virus; spumaretrovirus; cross-species virus transmission; zoonosis; restriction factors; immune responses; FV vectors; virus replication; latent infection; feline foamy virus; epidemiology; retrovirus; Spumaretrovirus; mountain lion; Puma concolor; ELISA; protease; reverse transcriptase; RNase H; reverse transcription; antiviral drugs; resistance; simian foamy virus; gibbon; lesser apes; co-evolution; complete viral genome; equine foamy virus; isolation; Japan; sero-epidemiology; reptile foamy virus; endogenous foamy virus; endogenous retrovirus; ancient retroviruses; co-speciation; foamy virus-host interactions; viral tropism; infection; kidney; cats; chronic kidney disease; chronic renal disease; integrase; integration; co-infections; NHP; pathogenesis; zoonoses; viral prevalence; Neotropical primates; free-living primates; Brazil; new world primates; simian retrovirus; BFV; spuma virus; model system; animal model; animal experiment; miRNA function; gene expression; antiviral host restriction; gene therapy; in-vivo gene therapy; hematopoietic stem and progenitor cells; foamy virus vector; pre-clinical canine model; SCID-X1; innate sensing; cGAS; STING; foamy viruses; wild ruminants; European bison; red deer; roe deer; fallow deer; seroreactivity; inter-species transmission; HSC; gene marking; FV gene transfer to HSCs; gene therapy alternatives; serotype; high-throughput sequencing; replication kinetics; cytopathic effect; reverse transcriptase activity; miRNA expression; virus-host-interaction; miRNA target gene identification; innate immunity; ANKRD17; Bif1 (SH3GLB1); replication in vitro
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine...