Animal Modeling in Cancer

• Other Authors: Korinek, Vladimir (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; soy; isoflavones; mammary tumor prevention; rodent models; chemical carcinogens; transgenic mice; Zebrafish; Drosophila; rats; mice; NPM-1; FLT3 ITD; ETO-1; IDH1/2; neural stem cells; brain and nervous system cancers; neurogenic niches; radiotherapy; sparing of neurogenic regions; carcinoma; consensus molecular subtypes; intestine; oncogenes; signaling cascades; tumor suppressors; tumorigenesis; MPN (myeloproliferative neoplasms); zebrafish; iPSCs; JAK2; MPL; CALR; thrombosis; ubiquitin-proteasome system; cancer; mouse model; gene inactivation; colorectal cancer; mouse models; microbiota; antitumor immunity; melanoma; mutation; genetics; animal model; swine; MeLiM; progression; spontaneous regression; devitalization; metaplasia; Cdx; animal models; epigenetics; xenotransplantation; drug screen; pre-clinical cancer model; non-mouse models; gene editing; stem cells; solid tumors; hematologic malignancies
• Online Access: DOAB: download the publication; DOAB: description of the publication

Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to...