Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics

• Other Authors: Vlajkovic, Srdjan M (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; brain-derived neurotrophic factor; TrkB; inner ear; development; zebrafish; mitochondria dysfunction; reactive oxygen species; hypoxic; d-galactose; high-fat diet; aging; hearing loss; astrocytes; auditory brainstem; lateral superior olive; gap junctions; voltage-activated calcium channel 1.3; otoferlin; spontaneous activity; deafness; circadian dysregulation; clock genes; noise-induced hearing loss; sensory hair cells; synaptic ribbons; sensorineural hearing loss; hyperbaric oxygenation; adjunctive therapy; microRNAs; cochlear nucleus; inferior colliculus; neuroplasticity; noise-induced cochlear injury; cochlear rescue; otoprotection; adenosine A1 receptor; regulator of G protein signalling 4; CCG-4986; intratympanic drug delivery; potassium voltage-gated channel subfamily q member 4; potassium; nonsyndromic hearing loss; KCNQ4 activator; age-related hearing loss; selegiline; chronic oral treatment; hearing protection; mouse model; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a time...