Mitochondria: From Physiology to Pathology

Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translatio...

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Bibliographic Details
Other Authors: Bruni, Francesco (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
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DOAB: description of the publication
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520 |a Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic 'hubs' are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue 'Mitochondria: from Physiology to Pathology' published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control. 
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653 |a carotid intima-media thickness 
653 |a mitochondrial mutations 
653 |a cardiovascular risk factors 
653 |a mitochondria 
653 |a mtDNA 
653 |a cristae 
653 |a mitochondrial fission 
653 |a mitochondrial fusion 
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653 |a mitoenergetics 
653 |a mitosteroidogenesis 
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653 |a cAMP 
653 |a Leydig cell 
653 |a mitochondrial DNA segregation 
653 |a heteroplasmy 
653 |a selective elimination 
653 |a mitophagy 
653 |a mitochondrial engineered nucleases 
653 |a kinases 
653 |a phosphorylation 
653 |a disease 
653 |a PINK1 
653 |a Parkinson's disease 
653 |a mitochondria homeostasis 
653 |a Cterm 
653 |a MELAS 
653 |a transmitochondrial cybrids 
653 |a aminoacyl-tRNA synthetases 
653 |a LARS2 
653 |a mitochondrial disease 
653 |a therapeutic peptides 
653 |a FAD synthase 
653 |a FAD1 
653 |a mitochondria localization 
653 |a Saccharomyces cerevisiae 
653 |a mRNA 
653 |a mitochondrial localization motif 
653 |a n/a 
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