The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder

• Other Authors: Leone, Marilisa (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; mass spectrometric epitope mapping; gas phase immune complex dissociation; apparent gas phase dissociation constants; apparent gas phase activation energies; ITEM-TWO; native mass spectrometry; TRIOBP; cancer; deafness; hearing loss; mental illness; schizophrenia; actin; cytoskeleton; disordered structure; protein aggregation; solid-state NMR; ELDOR-detected NMR; ATP hydrolysis; ATP analogues; DnaB helicase; ABC transporter; biopesticides; antifungal activity; insecticidal activity; mechanism of action; transgenic crops; protein folding; NMR; High Hydrostatic Pressure; ACE2; viral spike receptor-binding domain; SARS-CoV-2; transmission; bioinformatics; IDP 1; binding 2; molecular dynamics 3; MELD×MD 4; advanced sampling 5; p53 6; MDM2 7; NAD(P)H-dependent oxidoreductase; zinc-containing alcohol dehydrogenase; cofactor binding and release; interdomain cleft dynamics; molecular dynamics simulations; denatured state ensemble; protein coil library; peptides; intrinsically disordered proteins; ion-pairing interaction; side-chain length; charged amino acids; β-hairpin; peptide; Friedman's test; backbone atom coordinate variances and uncertainties; superimposition; nanobody; protein structure; immunoglobulin domain; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with dive...